Molybdenum trioxide (MoO3) has been considered an advanced auxiliary support for Pt nanoparticle anchorage due to its excellent activity and stability. Nevertheless, its non conductivity property still impedes its applications in electrocatalytic fields. Thus, the MoO3 and carbon composite of a nanostructure is synthesized through sintering process and served as an efficient co-support for Pt-based anode catalyst in this paper. The electrochemical measurements demonstrate that Pt/MoO3-C catalyst shows higher catalytic activity and stability than the as-prepared Pt/C. Significantly, it exhibits 1.95 times higher activity and 2.36 times better durability for methanol oxidation when compared with commercial Pt/C. The remarkably enhanced performance of this novel Pt/MoO3-C catalyst for methanol electrooxidation can be ascribed to the abundant Pt nucleation active sites, uniformly dispersed Pt nanoparticles and the strong metal-support interaction between Pt and MoO3-C. These outstanding properties suggest Pt/MoO3-C a promising catalyst for practical application of fuel cell. (C) 2016 Hydrogen Energy Publications LLC. Published by Elsevier Ltd. All rights reserved.