The present article is intended to analyze the effect of entropy generation on peristaltic flow of nanoparticles in a rotating frame. The flow is influenced by an external magnetic field. Viscous dissipation and thermal radiation effects are considered for modeling energy equation. The nonlinearity of resulting problem is simplified by adopting lubrication approach. Exact solutions for streamlines, velocity and temperature are calculated. Effective heat transfer is also studied via graphs. Moreover, It is noticed that temperature decays for larger radiation. An increase in internal heat generation enhances the temperature. Entropy generation N-s is an increasing function of radiation. (C) 2017 Elsevier Ltd. All rights reserved.