We present an experimental study on the flow behaviour of gas and liquid in the upward section of a vertical pipe system with an internal diameter of 101.6 mm and a serpentine geometry. The experimental matrix consists of superficial gas and liquid velocities in ranges of 0.15-30 m/s and from 0.07 to 1.5 m/s, respectively, which cover bubbly to annular flow. The effects on the flow behaviours downstream of the 180 return bend are significantly reduced when the flow reaches an axial distance of 47 pipe diameters from the U-bend. Therefore, reasonably developed flow is attained at this development length downstream of the bend. Other published measurements for large-diameter film thickness show similar trends with respect to the superficial gas velocity. However, the trends differ from those of small diameter pipes, with which the film thickness decreases much faster with increasing gas flow. As a result, only a few of the published correlations for small pipe data agreed with the experimental data for large pipe film thickness. We therefore modified one of the best-performing correlations, which produced a better fit. Qualitative and statistical analyses show that the new correlation provides improved predictions for two-phase flow film thickness in large-diameter pipes. (C) 2016 Elsevier Ltd. All rights reserved.