A novel reactor was developed for ultrasound-assisted liquid-liquid extraction. This reactor design entails introducing short contact intervals for the nlicrochannel tubing along the reactor plate channel to have a more focused transmission of the ultrasound. The non-contacted parts of the tubing are still under the influence of the ultrasound as a result of the pseudo-sonicated zone created by the adjacent intervals. The effect of introduction of these elements was first studied by compating the thermal profiles with and without the presence of intervals and it was found that the maximum intensities along the channel become focused at these intervals. The influence of the intervals on a sonicated two-phase flow was also studied and revealed a repetitive splitting (at the intervals) and coalescence (downstream from the interval) of the emulsified aqueous phase. This dynamic change in the size of the emulsified aqueous phase introduces additional interfacial area and improves the mass transfer between the phases. The number of intervals was varied between three, five and seven. The five intervals showed the best performance. On comparing the five-interval design with a direct-contact design it was shown that the interval design gave the best improvement in yield for the process conditions studied. (C) 2016 Elsevier B.V. All rights reserved.