Mitochondrial activation signaling pathways are not clearly identified. Embryonic mitochondria activity is important for a successful pregnancy and live birth. Neogenin is a multi-functional receptor that contributes to embryo development. Neogenin as a receptor is related to mitochondrial activation and replication. Neogenin could activate mitochondria in pre-implantation embryo development. (C) 2016 Elsevier Inc. All rights reserved.