Gliomas are the most common and aggressive primary malignant tumor in the central nervous system, and requires new biomarkers and therapeutic methods. Long noncoding RNAs (IncRNAs) are important factors in numerous human diseases, including cancer. But studies on lncRNAs and gliomas are limited. In this study, we investigated the expression patterns of IncRNAs in 3 pairs of glioma samples and adjacent non-tumor tissues via microarray and selected the most down-regulated Inc00462717 to further verify its roles in glioma. We observed that decreased lnc00462717 expression was associated with the malignant status in glioma. In vitro experiment demonstrated that Inc00462717 overexpression suppressed glioma cell proliferation, survival and migration while knockdown of Inc00462717 had an opposite result. Moreover, we identified MDM2 as a direct target of lnc00462717 and Inc00462717 played a role by partially regulating the MDM2/MAPK pathway. In conclusion, Inc00462717 may function in suppressing glioma cell proliferation, survival, migration and may potentially serve as a novel biomarker and therapeutic target for glioma.(C) 2017 Elsevier Inc. All rights reserved.