The known hydrocarbon synthesis technologies from synthesis gas through methanol and/or dimethyl ether (DME), which were implemented in different scales plants are analyzed. Common features, advantages, and disadvantages of each technology have been noted. Several designs of TIPS RAS GTL-technology based on the original DME single-step and gasoline catalysts have been calculated and the influence of the syngas composition on the gasoline specific yield for the optimal design has been studied.