A simple and effective route was established to regulate the drug release kinetics of hydrogels through a combination method of the polysaccharides matrix which delivers the drug and the mesoporous silica nanoparticles (MSN) as a reservoir, making the system release the payload in a controlled manner. The composite MSN beads can construct one kind of novel sustained drug administration device maintaining 24 h activity. With the increase of the MSN ratio in the beads, the sustained-release profile can be increased. The drug release kinetics provide clear evidence that the composite MSN beads delivery systems can protect the model drug of bovine serum albumin from external denaturants and release them slowly in a predictable model. These composite MSN beads with higher drug-loading capacity and better retention ability may facilitate sustained/controlled drug delivery systems for pharmaceutical and biomedical applications.