A microfluidic-based method for the continuous synthesis of Ag@Cu2O core-shell nanoparticles (NPs) has been developed. It only took 32 s to obtain Ag@Cu2O core-shell NPs, indicating a high efficiency of this microfluidic-based method. Triangular Ag nanoprisms were employed as the cores for the overgrowth of Cu2O through the reduction of Cu(OH)(4) with ascorbic acid. The as-synthesized samples were characterized by XRD, TEM, SEM, HAADF-STEM, EDX, HRTEM, UV-vis spectra and N-2 adsorption-desorption. The characterization results revealed that the as-synthesized Ag@Cu2O core-shell NPs exhibited a welldefined core-shell nanostructure with a polycrystalline shell, which was composed of numbers of Cu2O domains epitaxially growing on the triangular Ag nanoprism. It was concluded that the synthesis parameters such as the molar ratio of trisodium citrate to AgNO3, H2O2 to AgNO3, NaOH to CuSO4, ascorbic acid to CuSO4 and AgNO3 to CuSO4 had significant effect on the synthesis of Ag@Cu2O core-shell NPs. Moreover, Ag@Cu2O core-shell NPs exhibited superior catalytic activity in comparison with pristine Cu2O NPs towards the visible light-driven degradation of methyl orange. This enhanced photocatalytic activity of Ag@Cu2O core-shell NPs was attributed to the larger BET surface area and improved charge separation efficiency. The trapping experiment indicated that holes and superoxide anion radicals were the major reactive species in the photodegradation of methyl orange over Ag@Cu2O core-shell NPs. In addition, Ag@Cu2O core-shell NPs showed no obvious deactivation in the cyclic test. (C) 2016 Elsevier Inc. All rights reserved.