The density and sound velocity for pure alcohols (methanol, ethanol, iso-propanol and n-butanol) and molal solutions of nitroimidazoles (metronidazole (MNZ) and dimetridazole (DMZ) have been measured at different temperatures (293.15-313.15 K). Different volumetric and acoustical parameters like apparent molar volume (V-phi), partial molar volume (V-phi), apparent molar isentropic compressibility (K-phi), partial molar isentropic compressibility (K-phi), hydration number (n(H)), acoustic impedance (Z) and intermolecular free length (L-f) of antibiotic solutions were calculated from the experimental values of density and sound velocity. The derived values have been used to explore the solute-solute and solute-solvent interactions. The V-phi values are positive and K-phi values are negative in both antibiotics, indicative of strong solute-solvent interactions and closely packed structure of antibiotics in alcohols. The decreasing trend of L-f with increasing antibiotic concentration shows the presence of strong intermolecular interactions in solutions. (C) 2016 Elsevier Ltd.