Experimental solubility measurements for p-coumaric acid dissolved in nine neat organic solvents and in binary aqueous-ethanol solvent mixtures are used to calculate solute descriptors for the monomeric form of the carboxylic acid based on the Abraham solvation parameter model. The solute descriptors once calculated are used to predict the solubility of p-coumaric acid in additional organic solvents in which the carboxylic acid is expected to exist predominantly in monomeric form.