Design and control of fully heat-integrated pressure swing distillation for separating isobutyl alcohol and isobutyl acetate are explored. The steady state design and dynamic simulation are performed via Aspen Plus and Aspen Plus Dynamics, respectively. Some control structures for this process are put forward to hold the products purities. It is found that the control structure with pressure-compensated temperature control can effectively address feed flow rate and composition disturbances despite of small flaw. In order to address to this small flaw, the control structure with a cascade connection of pressure-compensated temperature and composition control is proposed and this control structure can precisely maintain the products purities. (C) 2016 Elsevier B.V. All rights reserved.