Toluene disocyanate (TDI) was used as a bridging molecule, a bridge bonding conjugated microsphere (FeTCPP-TDI-TiO2) was successfully prepared by grafting tetra-(carboxyphenyl) porphyrin iron (FeTCPP) on the surface of TiO2 microspheres. The FT-IR spectra revealed that the hydroxyl group (-OH) of TiO2 microspheres surface and the carboxyl group (-COOH) of FeTCPP reacted respectively with the active isocyanato groups (-NCO) of TDI to form a surface conjugated microsphere FeTCPP-TDI-TiO2. The UV-vis DRS analysis demonstrated that the formation of FeTCPP-TDI-TiO2 extended remarkably the photoresponse of as-prepared samples to visible light region. The photocatalytic activity of FeTCPP-TDI-TiO2 was evaluated using the photocatalytic degradation of norfloxacin (NFC), tetracycline (TC) and sulfapyridine (SPY) antibiotics in aqueous solution under visible-light irradiation. The results showed that, TDI, as a bond unit, was used to form a steady chemical bridging bond linking between FeTCPP and the surface of TiO2 microspheres, and the prepared catalyst exhibited higher photocatalytic activity under visible-light irradiation for antibiotics degradation in comparison with P25. The degradation of antibiotics all followed the pseudo first-order reaction model under visible light irradiation, and the degradation mechanisms of NFC, TC and SPY were also proposed. [GRAPHICS] .