The present work focuses on the fully developed mixed turbulent flow and heat transfer in receiver tube heated by non-uniform heat flux, especially the effect of local buoyancy force induced by the nonuniform heat flux at Reynolds number of 2 x 10(4)-10(5), Prandtl number of 1.5 and Grashof number of 0-1012. The friction factor and Nusselt number between forced convection and mixed convection under uniform heat flux and non-uniform heat flux are analyzed quantitatively. The effect of solar elevation angle on the fluid flow and heat transfer is also investigated. It is concluded that the mixed fluid flow and heat transfer under non-uniform heat flux is different from that under uniform heat flux. The solar elevation angle has strong influence on the mixed fluid flow and heat transfer characteristics. A criterion for the buoyancy free is proposed. It is not feasible to perform the heat transfer design and prediction for parabolic trough solar collector based on the experimental correlations for forced convection or conventional mixed convention. (C) 2015 Elsevier Ltd. All rights reserved.