Bio-supported catalysts, due to their green nature, are promising materials for coupling reactions. In this paper, the design and application of a new green cellulose Schiff base supported Pd(II) catalyst (CL-Sc-Pd) for the synthesis of different biaryls under microwave irradiation without the use of any organic solvent is reported. Firstly, a silane-modified cellulose Schiff base (CL-Sc) was synthesized as a support material, and then its heterogonous Pd(II) catalyst was easily prepared in water for the Suzuki coupling reaction. The synthesized materials were then characterized with various analytical tools. Finally, the catalytic performance of the green catalyst was investigated towards various C-C reactions using a green, simple and fast microwave technique. The catalyst indicated excellent selectivity and activity in a very short time (6 min) under a solvent-free media. In addition, outstanding TON (19,800) and TOF (198,000) values were obtained with the green Pd(II) catalyst The longevity of the green Pd(II) catalyst was studied and it was found to be reusable for at least eight runs. CL-Sc-Pd catalyst showed perfect catalytic efficiency for the Suzuki C-C reaction when it was compared to commercial palladium catalysts. (C) 2016 Elsevier B.V. All rights reserved.