화학공학소재연구정보센터
홈 로그인 로그아웃 연락처 사이트맵
Journal of Industrial and Engineering Chemistry, Vol.45, 430-439, January, 2017
DOI10.1016/j.jiec.2016.10.013  Export Citation
Antibacterial mechanism of ZnO nanoparticles under dark conditions
Ara Joe, Se-Ho Park, Kyu-Dong Shim, Da-Jung Kim, Kwang-Hwan Jhee, Hyo-Won Lee1, Cheol-Ho Heo1, Hwan-Myung Kim1, and Eue-Soon Jang†
  • Department of Applied Chemistry, Kumoh National Institute of Technology, Gumi, Gyeongbuk 730-701, Republic of Korea
  • 1Department of Chemistry & Division of Energy Systems Research, Ajou University, Suwon 443-749, Republic of Korea
E-mail:
To evaluate the antibacterial activity of zinc oxide (ZnO) in the absence of a light source, we examined three different types of nanoparticles that vary in size and the number of oxygen defect sites. Colony forming units (CFU) and various microscopic investigations revealed that the antibacterial activity of ZnO nanoparticles under dark conditions was not related to reactive oxygen species (ROS) generation and nanoparticles transfection, but depended on the ZnO attachment to bacterial cell walls and increasing concentrations of Zn2+ ions in the bacterial cytoplasm due to local dissolution of the attached ZnO.
Keywords:Zinc oxide;Antibacterial mechanism;Dark conditions;Reactive oxygen species;Zn2+ homeostasis
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