A series of indium tin oxide (ITO) supported palladium-cobalt binary metallic anode catalysts were prepared and used in the methanol oxidation reaction (MOR), which is a key reaction in direct methanol fuel cells (DMFCs), providing superior fuel. The morphology, composition, and electrocatalytic performance of Pd-x-Co/ITO (x = 5, 10 and 15) catalysts were characterized by scanning electron microscopy (SEM), energy-dispersive X-ray (EDX) spectroscopy, X-ray photoelectron spectroscopy (XPS), X-ray diffraction (XRD), cyclic voltammetry (CV), and chronoamperometric techniques. For comparison, Pd-x/ITO (x = 5, 10 and 15) catalysts were also tested under the same conditions. Compared with pure Pd nanoparticles on ITO (Pd/ITO), due to the participation of Co as a support, the as-prepared Pd-10-Co/ITO catalyst exhibited a lower onset potential, enhanced electrocatalytic activity, and better durability in the MOR in alkaline media without the use of other oxidants. Moreover, Pd-10-Co/ITO can significantly contribute to cost reduction when used as an anode catalyst for DMFCs. (C) 2016 The Electrochemical Society. All rights reserved.