The solubility of 3,7,9,11-tetraoxo-2,4,6,8,10-pentaaza[3.3.3]propellane (TOPAP) was measured in pure H2O and 11 other organic solvents, including methanol, acetonitrile, acetone, ethyl acetate, ethanol, tetrahydrofuran, n-propanol, i-propanol, dioxane, ethylene glycol, and toluene in the temperature range from 273.15 to 318.15 K at an interval of 5 K by the equilibrium method with ultraviolet detection. For all reagents selected, the results showed that the solubility data of TOPAP increased with increasing temperature. All of the obtained experimental results in all mentioned solvents were correlated with temperature by using the ideal solution model, Apelblat model, Yaws model, lambda h equation, and NRTL model. The ideal solution model, Apelblat model, Yaws model, and lambda h equation are more suitable for the correlations of solubility of TOPAP, and they have a smaller maximum relative average deviation.