The purpose of present study was to develop chemically cross-linked chitosan-co-poly(AMPS) hydrogel for pH-responsive and controlled delivery of valsartan. Hydrogels were synthesized using the free radical polymerization technique. A polymer (high molecular weight chitosan) was chemically cross-linked with monomer (2-acrylamido-2-methylpropane sulfonic acid (AMPS)) in aqueous medium. N'N'-Methylenebisacrylamide was used as a cross-linker. Sodium hydrogen sulfite and ammonium peroxodisulfate were used as initiators. Drug loading was performed with valsartan as a model drug. Characterization of hydrogels was performed by SEM, FTIR, and DSC. Hydrogels were evaluated for pH-responsive behavior by the equilibrium swelling ratio and swelling dynamics at low and high pH. The developed cross-linked network showed pH-dependent drug release characteristics. Maximum swelling, drug loading, and release have been observed at pH 7.4. It is concluded that highly stable chitosan and AMPS-based polymeric matrices are developed. These polymeric matrices have potential to be used as a carrier for controlled delivery of valsartan.