Monodisperse spherical Cu-Sn alloy powders were successfully synthesized via the reduction of mixture CuO-SnO2 powders coupled with in-situ de-wetting of liquid-solid interface. The alloy droplets were divided into small units using a graphite sea as solid dispersant to suffer from agglomeration. Fully dense without pores and bulk inclusions, the cross-sectional micrographics of the spherical alloy particles indicate an evenly distribution of the Cu and Sn. The Cu-Sn alloy powders exhibit a good spherical shape and smooth surface, suggesting that the liquid Cu-Sn alloy completely de-wets from the graphite surface. Our strategies are expected to provide a new route for fabrication of high-quality spherical Cu-Sn alloy powders via the reduction of mixture metal oxides. (C) 2016 Elsevier B.V. All rights reserved.