The organic electrochemical transistor (OECT), capable of transducing small ionic fluxes into electronic signals in an aqueous environment, is an ideal device to utilize in bioelectronic applications. Currently, most OECTs are fabricated with commercially available conducting poly(3,4-ethylenedioxythiophene) (PEDOT)based suspensions and are therefore operated in depletion mode. we present a series of semiconducting polymers designed to elucidate important structure property guidelines required for accumulation mode OECT operation. We discuss key aspects relating to QECT performance such as ion and hole transport, electrochromic properties, operational voltage, and stability.. The demonstration of Our molecular design strategy is the fabrication of accumulation mode OECTs that clearly outperform state-of-the-art PEDOT-based devices, and show stability under aqueous operation without the need,for formulation additives and cross-linkers.