In this work, the solubility of the form A of ibrutinib in isopropanol (IPA), 1-butanol, ethyl acetate (EA), acetonitrile, acetone, methyl ethyl ketone (MEK) and methyl tertiary butyl ether (MTBE) was firstly experimentally determined by a gravimetric method in the temperature range from 278.15 to 323.15 K at atmospheric pressure. The experimental solubility data were correlated by several commonly used models including the modified Apelblat equation, the Buchowski-Ksiazczak lambda h equation and an empirical quartic polynomial equation. The results showed that, in the temperature range investigated, the solubility of ibrutinib generally increased with the increasing temperature, and the solubility order at the room temperature in the studied solvents was: MEK > acetone > ethyl acetate > 1-butanol > acetonitrile approximate to isopropanol > MTBE. In addition, all the models gave satisfactory correlation results, in which the empirical quartic polynomial equation stood out to be more suitable with a higher accuracy than the other two equations. (C) 2016 Elsevier Ltd.