The catalytic performance of Pt-based nanocatalysts is closely related to the morphology and structure of the catalysts. We report herein the preparation of novel PtPd nanocatalysts with a hollow structure through a special galvanic replacement reaction and the high reaction selectivity of one kind of triblock pluronic copolymers. P123 (PEO19-PPO69-PEO19) has unique selectivity for the reduction of K2PdCl4 and K2PtCl6. Relative to the commercial Pt/C and PtPd alloy catalysts, the PtPd nanocatalysts exhibited enhanced electrocatalytic activity toward methanol oxidation. The excellent electrocatalytic activity is due to the unique structure of PtPd nanocataysts. (C) 2016 Elsevier Ltd. All rights reserved.