Inspired from a real case study of a Saudi oil company, this work addresses the optimal operation of a regional network of gas oil separation plants (GOSPs) in Arabian Gulf Coast Area to ultimately achieve higher savings in operating expenditures (OPEX) than those achieved by adopting single-surface facility optimisation. An originally tailored and integrated mixed integer linear programming (MILP) model is proposed to optimise the crude transfer through swing pipelines and equipment utilisation in each GOSP, to minimise the operating costs of a network of GOSPs. The developed model is applied to an existing network of GOSPs in the Ghawar field, Saudi Arabia, by considering 12 different monthly production scenarios developed from real production rates. Compared to rule-based current practice, an average 12.8% cost saving is realised by the developed model. (C) 2016 Institution of Chemical Engineers. Published by Elsevier B.V. All rights reserved.