Superfluorinated PEI Derivative Coupled with Tc-99m for ASGPR Targeted F-19 MRI/SPECT/PA Tri-Modality Imaging

Guo ZD; Gao MN; Song ML; Li YS; Zhang DL; Xu D; You LY; Wang LL; Zhuang RQ; Su XH; Liu T; Du J; Zhang XZ

Advanced Materials, Vol.28, No.28, 5898-5898, 2016

DOI10.1002/adma.201601064 Export Citation

Superfluorinated PEI Derivative Coupled with Tc-99m for ASGPR Targeted F-19 MRI/SPECT/PA Tri-Modality Imaging

Guo ZD, Gao MN, Song ML, Li YS, Zhang DL, Xu D, You LY, Wang LL, Zhuang RQ, Su XH, Liu T, Du J, Zhang XZ

Fluorinated polyethylenimine derivative labeled with radionuclide Tc-99m is developed as a F-19 MRI/SPECT/PA multifunctional imaging agent with good asialoglycoprotein receptors (ASGPR)-targeting ability. This multifunctional agent is safe and suitable for F-19 MRI/SPECT/PA imaging and has the potential to detect hepatic diseases and to assess liver function, which provide powerful support for the development of personalized and precision medicine.