Three new bioactive silver(I) coordination polymers formulated as [Ag-2(mu(2)-PTA)(mu(3)-PTA)(mu(2)-pga)(H2O)]center dot 6H(2)O (1), [Ag-2(mu(2)-PTA)(mu(3)-PTA)(Hpmal)(2)]center dot 2H(2)O (2), and [Ag(mu(3)-PTA) (Hdmga)](n) (3) were self assembled from Ag2O, 1,3,5-triaza-7-phosphaadamantane (PTA), and a substituted dicarboxylic acid (3-phenylglutaric acid (H(2)pga), phenylmalonic acid (H(2)pma1), or 3,3-dimethylglutaric acid (H(2)dmga)) as an ancillary ligand. Compounds 1-3 were fully characterized by IR and NMR spectroscopy, ESI-MS(+/-), elemental analysis, and single-crystal X-ray diffraction, revealing that their architectural and topological diversity is governed by structural modulation of a dicarboxylate building block. The structures vary from a ID cyclic chain with the SP 1-periodic net (4,4)(0,2) topology in 2 to distinct 2D metal organic layers with the cem-d and hcb topologies in 1 and 3, respectively. In addition, compounds 1-3 exhibit a notable antimicrobial efficiency against a panel of common Gram-negative (E. coil and P. aeruginosa) and Gram-positive (S. aureus) bacteria and yeast (C. albicans). The best normalized minimum inhibitory concentrations (normalized MIC) of 11-23 nmol mL(-1) (for bacterial strains) or 68 nmol mL(-1) (for a yeast strain) are shown by compound 2, and the eventual structure bioactivity correlations are discussed.