An economical and easy to scale up method for glycerol conversion to solketalacetin (i.e., (2,2-dimethyl-1,3-dioxolan-4-yl)methyl acetate) as a valuable fuel additive is described, for the first time. Monoacetin was synthesized by reacting glycerol with acetic acid, and then solketalacetin was produced from the reaction of monoacetin with acetone using Purolite PD 206 as a catalyst. The central composite design was employed for the experimental design and then response surface methodology was used for the optimization of variables for the second stage of the reaction. The optimum operating conditions for the second stage of the reaction were as follows: acetone to monoacetin mole ratio, 5; reaction temperature, 20 degrees C; pressure, 45 bar; flow rate, 0.2 mL.min(-1); and catalyst, 2.0 g. Yield of the second stage of the reaction at the experimental design conditions and at the acetone to monoacetin mole ratio of 9 was obtained as 69% and 100%, respectively.