In this research; an experiment was conducted by introducing superhydrophobic surface into rolling spheronization granulation. The employed superhydrophobic surface was prepared with modification of an anodized Cu mesh with silane FAS-17 and exhibited excellent uniformity, adequate stability, and broad adaptability in the: granulation scenario. Completely, spherical-molecular sieve granules with 99.85% sphericity and 2.53 mm diameter were obtained. The compressive strength of a single granule reached, 7.402 N/ea. Only negligible residual mass and slight: surface abrasion were observed in the granulation process. Force analysis confirmed that the staged motion behavior of droplets, caused by the interaction between the slurry and the superhydrophobic surface benefited to the formation of spherical granules. Successful application of this process for granulation of other substances confirmed its wide suitability. With the advantages of easy fabrication, high-quality granules, rolling-spheronization granulation on superhydrophobic surfaces has great potential for scale-up applications.