Given the growing concern about building energy efficiency and the difficulty in applying complex simulation tools during retrofit practices, the need for easily and quickly estimating the building energy performance becomes pressing. As a pilot test, this study proposes a systematic method to develop a model, which can immediately assess the annual electricity consumption for office buildings with fan coil system in Shanghai. First, a base-case building model is established by EnergyPlus to create a pool of candidate inputs using orthogonal experiment design. Then, analysis of variance is used to identify a total of 10 key building design parameters, which are selected as the input variables in the support vector regression (SVR) model based on a well-structured database. The performance of SVR is optimized using genetic algorithm (GA) based on radial basis function kernel. Finally, two real office buildings in Shanghai with reliable measured data serve to evaluate the developed hybrid model. The resulting differences between the predicted and measured values are generally within 10%. It is expected that the developed database and model can be used to assess the likely energy savings penalty related with certain parameter changes to some extent during the retrofit process for office buildings. (C) 2016 Elsevier B.V. All rights reserved.