Smog chamber Fourier transform infrared techniques were used to investigate the kinetics of the reaction of CF3CF2OCH3 with Cl atoms and OH radicals: k(Cl + CF3CF2OCH3) = (1.09 +/- 0.16) x 10(-13) and k(OH + CF3CF2OCH3) = (1.28 +/- 0.19) x 10(-14) cm(3) molecule(-1) s(-1) in 700 Torr total pressure of N-2/O-2 at 296 +/- 2 K. The Cl-initiated oxidation of CF3CF2OCH3 gives CF3CF2OCHO in a yield indistinguishable from 100%. An estimate of k(Cl + CF3CF2OCHO) = (1.18 +/- 0.34) x 10(-14) cm3 molecule(-1) s(-1) is provided. Based on the OH reaction rate, the atmospheric lifetime of CF3CF2OCH3 is estimated to be 5.0 years. The 100-year time horizon global warming potential of CF3CF2OCH3 is estimated to be 585. The atmospheric impact of CF3CF2OCH3 is discussed. (C) 2016 Elsevier B.V. All rights reserved.