We have developed ZnFe2O4 magnetic nanoparticles/reduced graphene oxide nanosheets modified glassy carbon (ZnFe2O4/rGOIGCE) electrode as a novel system for the electrochemical glucose sensing. Via a facile in situ hydrothermal route, the reduction of GO and the formation of ZnFe2O4 nanoparticles occurred simultaneously. This enables the ZnFe2O4 nanoparticles dispersed on the reduced graphene sheet. Characterization of nanocomposite by X-ray diffraction (XRD) and transmission electron microscopy (TEM) clearly demonstrate the successful attachment of ZnFe2O4 nanoparticles to graphene sheets. Electrochemical studies revealed that the ZnFe2O4/rGOIGCE possess excellent electrocatalytic activities toward the oxidation of glucose and the performance of sensor is enhanced by integration of graphene nanosheets with ZnFe2O4 nanoparticles. (C) 2016 Elsevier B.V. All rights reserved.