Hydrazine-modified starch coated magnetic nanoparticles as an effective pH-responsive nanocarrier for doxorubicin delivery

Nasrin Zohreh; Seyed Hassan Hosseini; Ali Pourjavadi

Journal of Industrial and Engineering Chemistry, Vol.39, 203-209, July, 2016

DOI10.1016/j.jiec.2016.05.029 Export Citation

Hydrazine-modified starch coated magnetic nanoparticles as an effective pH-responsive nanocarrier for doxorubicin delivery

Nasrin Zohreh^†, Seyed Hassan Hosseini¹, and Ali Pourjavadi¹

Department of Chemistry, Faculty of Science, University of Qom, P. O. Box: 37185-359, Qom, Iran
¹Polymer Research Laboratory, Department of Chemistry, Sharif University of Technology, Tehran, Iran

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A novel, magnetic nanocarrier was successfully synthesized through a facile and economical producer in which Fe3O4 magnetic nanoparticles were coated by starch-g-poly (methyl methacrylate-co-PEG-acrylamide). The surface of nanocarrier was then modified by hydrazine to preparation of a pHresponsive carrier. The resulted nanocarrier was applied for delivery of doxorubicin (DOX) as an effective anti-cancer drug. DOX was reacted with hydrazine linkage on the surface of nanocarrier to form hydrazone bond. Due to the presence of numerous hydrazine groups on the surface of magnetic nanocarrier large amounts of DOX was loaded onto the carrier (327 mg g-1).

Keywords:Magnetic nanocarrier;Drug delivery;Doxorubicin;Starch;pH-sensitive

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[Referenced By]

[1] Sun C, Lee JS, Zhang M, Adv. Drug Deliv. Rev., 60, 1252 (2008)

[2] Veiseh O, Gunn JW, Zhang M, Adv. Drug Deliv. Rev., 62, 284 (2010)

[3] Dobson J, Drug Dev. Res., 67, 55 (2006)

[4] Jaiswal MK, Gogoi M, Sarma HD, Banerjee R, Bahadur D, Biomater. Sci., 2, 370 (2014)

[5] Kumar CS, Mohammad F, Adv. Drug Deliv. Rev., 63, 789 (2011)

[6] Chertok B, Moffat BA, David AE, Yu F, Bergemann C, Ross BD, Yang VC, Biomaterials, 29, 487 (2008)

[7] Mody VV, Cox A, Shah S, Singh A, Bevins W, Parihar H, Appl. Nanosci., 4, 385 (2014)

[8] Reddy LH, Arias JL, Nicolas J, Couvreur P, Chem. Rev., 112(11), 5818 (2012)

[9] Cheng K, Sun Z, Zhou Y, Zhong H, Kong X, Xia P, Guo Z, Chen Q, Biomater. Sci., 1, 965 (2013)

[10] Gonzalez-Moragas L, Yu SM, Carenza E, Laromaine A, Roig A, ACS Biomater. Sci. Eng., 1, 1129 (2015)

[11] Chung HJ, Lee H, Bae KH, Lee Y, Park J, Cho SW, Hwang JY, Park H, Langer R, Anderson D, ACS Nano, 5, 4329 (2011)

[12] Lee JH, Jun YW, Yeon SI, Shin JS, Cheon J, Angew. Chem.-Int. Edit., 118, 8340 (2006)

[13] Singh A, Sahoo SK, Drug Discov. Today, 19, 474 (2014)

[14] Cheng Z, Dai Y, Kang X, Li C, Huang S, Lian H, Hou Z, Ma P, Lin J, Biomaterials, 35, 6359 (2014)

[15] Ye F, Barrefelt A, Asem H, Abedi-Valugerdi M, El-Serafi I, Saghafian M, Abu-Salah K, Alrokayan S, Muhammed M, Hassan M, Biomaterials, 35, 3885 (2014)

[16] Wang H, Shen J, Li Y, Wei Z, Cao G, Gai Z, Hong K, Banerjee P, Zhou S, Biomater. Sci., 2, 915 (2014)

[17] Kohler N, Sun C, Fichtenholtz A, Gunn J, Fang C, Zhang M, Small, 2, 785 (2006)

[18] Arruebo M, Fernandez-Pacheco R, Ibarra MR, Santamaria J, Nano Today, 2(3), 22 (2007)

[19] Torkpur-Biglarianzadeh M, Salami-Kalajahi M, RSC Adv., 5, 29653 (2015)

[20] Pourjavadi A, Tehrani ZM, Hosseini SH, RSC Adv., 5, 48586 (2015)

[21] Pourjavadi A, Hosseini SH, Alizadeh M, Bennett C, Colloids Surf. B: Biointerfaces, 116, 49 (2014)

[22] Urries I, Munoz C, Gomez L, Marquina C, Sebastian V, Arruebo M, Santamaria J, Nanoscale, 6, 9230 (2014)

[23] Ling D, Lee N, Hyeon T, Acc. Chem. Res., 48 (2015)

[24] Li Y, Lin R, Wang L, Huang J, Wu H, Cheng G, Zhou Z, MacDonald T, Yang L, Mao H, J. Mater. Chem. B, 3, 3591 (2015)

[25] Hałupka-Bryl M, Bednarowicz M, Dobosz B, Krzyminiewski R, Zalewski T, Wereszczynska B, Nowaczyk G, Jarek M, Nagasaki Y, J. Magn. Magn. Mater., 384, 320 (2015)