Smart assemblies have been widely studied in recent years for their capability to respond to the environment. As a series of building blocks of smart assemblies, multi-stimuli responsive polymers have also attracted a great deal of attention. In this article, notable recent advances in the fields of synthesis and assembly of amine-containing polyethers are summarized. Amine-containing polyethers, which combine the excellent biocompatibility and temperature responsive behaviour of polyethylene glycols with the pH responsive behaviour and ease of functionality of amines, are ideal building blocks for fabricating smart assemblies. 0-D, 1-D, and 2-D smart assemblies have already been obtained from assembly of amine-containing polyethers, and they show much promise in the areas of disease diagnosis and targeting, drug delivery system, molecular recognition and separation, polymeric templates, and more. (C) 2016 Elsevier Ltd. All rights reserved.