Fuel-coolant interaction (FCI) is a very complex but important issue in the safety analysis of the severe accidents for nuclear reactors due to the rapid multiple thermos-hydrodynamic activities. Until now, there are still large uncertainties existing in various phases during the FCI process, such as the melt solidification, fragmentation and relocation, film boiling on the melt surface, coolant vaporization and following vapor explosion, and so on. SIMMER-III code was first developed to analyses core disruptive accidents in liquid-metal fast reactors (LMFRs) as an integral numerical tool coupling multiphase thermal hydraulic code with neutron kinetics model, and was demonstrated its reasonable flexibility in some FCI simulations. In this paper, the applicability of the code in simulating the premixing phase of FCI process is verified in comparison with a related jet-type experiment in literature. In addition, the sensitivity analysis on several key parameters of the related models in the SIMMER code was performed to assess the impacts in the simulation of the FCI premix phase. It is expected that the results can provide some numerical experience for the uncertainty analysis of FCI calculation using SIMMER-III code. Copyright (C) 2016, Hydrogen Energy Publications, LLC. Published by Elsevier Ltd. All rights reserved.