This research assessed impacts of drilling for gas in the Marcellus shale by monitoring water quality. Both a stream with an active drilling operation and a reference stream were monitored. Differences at the active reach were detected in turbidity, pH, conductivity, total dissolved solids, Sr, Ca, Cl, Na, Mg, alkalinity, and SO4. Differences were largely attributed to an expanded roadway, and the ranges of most measured parameters were within range of water quality criteria for West Virginia.