The thermodynamic and kinetic hydrates inhibition effects of addition of synergents poly(ethylene oxide) (PEO) and vinyl caprolactum (VCAP) with ionic liquids 1-methyl-l-propylpyrrolidinium chloride [PMPy] [Cl] and 1-methyl-1-propylpyrrolidinium triflate [PMPy] [triflate] were studied on a synthetic quaternary gas mixture (methane, C-1 = 84.20%; ethane, C-2 = 9.90%; n-hexane, C6+ = 0.015%; CO2 = 2.46%; N-2 = 2.19%). The results show that the addition of synergents with ionic liquids helps to improve their thermodynamic and kinetic hydrate inhibition effectiveness simultaneously.