Efficient morphology modulation of a red AIEgen from pristine microsized rods to nanospheres is achieved via encapsulating QM-2 (quinoline-malononitrile-2) into hybrid micelles. This novel reagent shows great potential in tumor-targeted bioimaging because of its monodispersion in aqueous systems, the uniform diameter of approximate to 30 nm, enhanced fluorescence brightness with a large Stokes shift of 190 nm, and strongly increased biocompatibility and photostability.