Effect of bio-template on the properties of SiO2/Al2O3 composites for drug delivery

Long-Yue Meng; Weiqi Jiang; Wenxiang Piao; Wan Meng

Journal of Industrial and Engineering Chemistry, Vol.37, 14-17, May, 2016

DOI10.1016/j.jiec.2016.02.012 Export Citation

Effect of bio-template on the properties of SiO2/Al2O3 composites for drug delivery

Long-Yue Meng, Weiqi Jiang¹, Wenxiang Piao¹, and Wan Meng^{1, †}

Key Laboratory of Natural Resources of Changbai Mountain and Functional Molecules, Yanbian University, Yanji 133002, China
¹Department of Chemistry, Yanbian University, Yanji 133002, China

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In this study, SiO2/Al2O3 composites (C-SLNs) were successfully synthesized using chitosan as the template for drug delivery. The C-SLNs had higher specific surface areas (244.607 m2/g), total pore volumes (0.19-0.34 cm3 g-1), and narrow mesopore size distribution. The porosity of the C-SLNs prepared under high Si/Al ratio conditions was achieved mostly by the formation of wider pores that were distributed in the meso-/macro-pores. And, the C-SLNs were used as a levofloxacin carrier to study its drug release behavior, which exhibited an initial fast release followed by a sustained release and antibacterial effectiveness over a long period.

Keywords:Chitosan;Template;Silica/alumina;Drug delivery;Levofloxacin

[References]

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Solanki AR, Kamath BV, Thakore SJ, Appl. Polym. Sci., 132, 42223 (2015)
Meng LY, Han SY, Jiang NZ, Meng W, Mater. Chem. Phys., 148(3), 798 (2014)
Meng LY, Rhee KY, Park SJ, J. Ind. Eng. Chem., 20(4), 1672 (2014)
Selvaggi R, Tarpani L, Santuari A, Giovagnoli S, Latterini L, Appl. Catal. B: Environ., 168-169, 363 (2015)
Ma C, Tarpani L, Huang Z, Feng J, Yao Y, Chen S, Chem. Mater., 23, 3583 (2011)
Yang G, Gai S, Qu F, Yang P, ACS Appl. Mater. Interfaces, 5, 5788 (2013)
Mahdizadeh F, Eskandarian M, J. Ind. Eng. Chem., 20(4), 2378 (2014)
Godnjavec J, Zabret J, Znoj B, Skale S, Veronovski N, Venturini P, Prog. Org. Coat., 77, 47 (2014)
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Li T, Shu Z, Zhou J, Chen Y, Yu D, Yuan X, Wang Y, Appl. Clay Sci., 107, 182 (2015)
Li Y, Li B, Yan Z, Huang Z, Hu K, Wang S, Yang Y, Chem. Mater., 25, 307 (2013)
Zhang Y, Liu X, Huang J, ACS Appl. Mater. Interfaces, 3, 3272 (2011)
Preethi T, Abarna B, Rajarajeswari GR, Appl. Surf. Sci., 319, 197 (2014)
Preethi T, Abarna B, Rajarajeswari GR, Appl. Surf. Sci., 317, 90 (2014)
Kadib AE, Molvinger K, Cacciaguerra T, Bousmina M, Brunel D, Microporous Mesoporous Mater., 142, 301 (2011)
Sifontes AB, Gonzalez G, Ochoa JL, Tovar LM, Zoltan T, Canizales E, Mater. Res. Bull., 46(11), 1794 (2011)
Witoon T, Chareonpanich M, Limtrakul J, Mater. Lett., 62, 1476 (2008)
He JA, Zhang AJ, Zhang YJ, Guan Y, Macromolecules, 44(7), 2245 (2011)
Wang Y, Zhao Q, Han N, Bai L, Li J, Liu J, Che E, Hu L, Zhang Q, Jiang T, Wang S, Nanomed.: NBM, 11, 313 (2015)

[Referenced By]

[1] Mura S, Nicolas J, Couvreur P, Nat. Mater., 12(11), 991 (2013)

[2] Lee PL, Good WR (Eds.), Controlled-release Technology, ACS Symposium Series, vol. 348, Ciba-Geigy Corporation, Ardsley, NY, 1987, p. 1 (Chapter 1).

[3] Li YY, Cunin F, Link JR, Gao T, Betts RE, Reiver SH, Chin V, Bhatia SN, Sailor MJ, Science, 28, 2045 (2013)

[4] Jia C, Song J, Jin Y, Rojas OJ, Appl. Polym. Sci., 132, 42562 (2015)

[5] Peng H, Cui B, Li G, Wang Y, Li N, Chang Z, Wang Y, Mater. Sci. Eng., 46, 253 (2015)

[6] Volodkin D, Adv. Colloid Interface Sci., 207, 306 (2014)

[7] Solanki AR, Kamath BV, Thakore SJ, Appl. Polym. Sci., 132, 42223 (2015)

[8] Meng LY, Han SY, Jiang NZ, Meng W, Mater. Chem. Phys., 148(3), 798 (2014)

[9] Meng LY, Rhee KY, Park SJ, J. Ind. Eng. Chem., 20(4), 1672 (2014)

[10] Selvaggi R, Tarpani L, Santuari A, Giovagnoli S, Latterini L, Appl. Catal. B: Environ., 168-169, 363 (2015)

[11] Ma C, Tarpani L, Huang Z, Feng J, Yao Y, Chen S, Chem. Mater., 23, 3583 (2011)

[12] Yang G, Gai S, Qu F, Yang P, ACS Appl. Mater. Interfaces, 5, 5788 (2013)

[13] Mahdizadeh F, Eskandarian M, J. Ind. Eng. Chem., 20(4), 2378 (2014)

[14] Godnjavec J, Zabret J, Znoj B, Skale S, Veronovski N, Venturini P, Prog. Org. Coat., 77, 47 (2014)

[15] Nazari A, Riahi S, Energy Build., 43(10), 2939 (2011)

[16] Wang JY, Li JH, Wang YJ, Luo GS, Chem. Eng. J., 236, 293 (2014)

[17] Li T, Shu Z, Zhou J, Chen Y, Yu D, Yuan X, Wang Y, Appl. Clay Sci., 107, 182 (2015)

[18] Li Y, Li B, Yan Z, Huang Z, Hu K, Wang S, Yang Y, Chem. Mater., 25, 307 (2013)

[19] Zhang Y, Liu X, Huang J, ACS Appl. Mater. Interfaces, 3, 3272 (2011)

[20] Preethi T, Abarna B, Rajarajeswari GR, Appl. Surf. Sci., 319, 197 (2014)

[21] Preethi T, Abarna B, Rajarajeswari GR, Appl. Surf. Sci., 317, 90 (2014)

[22] Kadib AE, Molvinger K, Cacciaguerra T, Bousmina M, Brunel D, Microporous Mesoporous Mater., 142, 301 (2011)

[23] Sifontes AB, Gonzalez G, Ochoa JL, Tovar LM, Zoltan T, Canizales E, Mater. Res. Bull., 46(11), 1794 (2011)

[24] Witoon T, Chareonpanich M, Limtrakul J, Mater. Lett., 62, 1476 (2008)

[25] He JA, Zhang AJ, Zhang YJ, Guan Y, Macromolecules, 44(7), 2245 (2011)

[26] Wang Y, Zhao Q, Han N, Bai L, Li J, Liu J, Che E, Hu L, Zhang Q, Jiang T, Wang S, Nanomed.: NBM, 11, 313 (2015)