화학공학소재연구정보센터
홈 로그인 로그아웃 연락처 사이트맵
Polymer(Korea), Vol.40, No.3, 380-384, May, 2016
DOI10.7317/pk.2016.40.3.380  Export Citation
난용성 약물인 Isoflavone계 화합물을 함유한 하이드로콜로이드 패치의 물리화학적 특성
Physicochemical Properties of the Poorly Soluble Isoflavone Class-loaded Hydrocolloid Patch
이선화, 심우선, 류종성, 박선규, 이천구, 김기현1, 정성훈1, 강내규†
  • LG생활건강 기술연구원
  • 1동국대학교 약학과
Sun Hwa Lee, Woo Sun Shim, Jong Seong Ryu, Sun Gyoo Park, Cheon Koo Lee, Ki Hyun Kim1, Seong Hoon Jeong1, and Nae Kyu Kang†
  • LG Household & Healthcare R&D center, Daejeon 34114, Korea
  • 1College of Pharmacy, Dongguk University, Gyeonggi 10326, Korea
E-mail:
초록
Genistein과 daidzein은 isoflavone 계열의 약물로써 다양한 암의 치료 및 예방, 항산화, 항염 활성 효과를 나타내는 물질이다. 그러나 이 약물들은 용해성이 좋지 않아 약물을 포함하는 크림 형태의 에멀젼에 적용하여 피부를 통해 전달하기 어렵다. 본 연구에서는 하이드로콜로이드 패치라는 TDDS(transdermal drug delivery system)를 이용하여 genistein과 daidzein과 같은 난용성 약물을 피부에 전달하였다. 패치가 에멀젼보다 피부로 잘 흡수되는 것을 돼지 피부(porcine skin)를 이용한 투과 실험 및 confocal microscopy로 확인하였으며, 이는 패치의 밀폐효과(occlusive effect)에 의해 피부 내로 잘 흡수된 것이다. 하이드로콜로이드 패치는 에멀젼 형태의 크림보다 난용성 약물을 피부내로 전달하는데 더 좋은 방법이며, 사용하기 편리하므로 효과적인 화장품으로써 가치가 있다.
Genistein and daidzein, phytoestrogens belonging to the isoflavone class, have a role in the treatment and prevention of various cancers, antioxidant and anti-inflammation activity. However, it is difficult to deliver through the skin from applying the emulsion such as cream containing them because these drugs are nearly insoluble in aqueous solutions. In this study, the hydrocolloid patch including poorly soluble drugs such as genistein and daidzein was used as the transdermal drug delivery system (TDDS) to deliver them through the skin. It was confirmed that the patches are helpful for the drugs to be absorb much and more deeply than the cream due to the occlusive effect of patch, which was verified from the porcine skin and the confocal microscopy. The hydrocolloid patch is a better way to deliver the poorly soluble drugs through the skin than the general cosmetics such as emulsion-based cream, and is valuable as effective cosmetics due to its convenient usage.
Keywords:genistein;daidzein;hydrocolloid patch;transdermal drug delivery;poorly soluble drug
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