Journal of Membrane Science, Vol.130, No.1-2, 17-21, 1997
Evaluation of Membranes of Copolypeptide of Gamma-Benzyl L-Glutamate and L-Glutamic Acid for the Permeability of Anticancer Drugs
The membranes of poly(gamma-benzyl L-glutamate-co-L-glutamic acid) [P(BLG-LGA)] were prepared by saponification of poly(gamma-benzyl L-glutamate) (PBLG) membranes. The permeation of two anticancer drugs, 5-fluoro-uracil (5-fu) and 2-hydroxyethyl-oxy-methyl-5-fluoro-uracil (2-HEOM-5-Fu), through these membranes was studied. The results showed a sharp increase in permeability of the copolymer membranes compared to the PBLG membranes.