Densities and speeds of sound of diphenhydramine hydrochloride (DPH) in aqueous solution and 0.06 mol.kg(-1) aqueous solutions of sodium chloride and myo-inositol (MI) have been measured at different temperatures, T = (288.15, 298.15 and 308.15) K over the concentration range (0.01 to 0.1) mol.kg(-1). Density and speed of sound values were used to evaluate thermodynamic properties such as apparent molar volume (V-phi), isentropic compressibility (kappa(s)) of solution, apparent molar isentropic compressibility (kappa(phi)) of solute, of diphenhydramine hydrochloride in water and in aqueous solutions of sodium chloride and myo-inositol. The limiting apparent molar expansivity (E-phi(0)) of solute and coefficient of thermal expansion (alpha*) of DPH in aqueous binary and ternary solutions have also been computed. Limiting values of apparent molar volume (V phi(0)) and apparent molar compressibility (kappa(0)(phi)) were obtained from the plots V-phi and kappa(phi) as a function of molality and have been utilized in obtaining transfer volumes (Delta V-tr(phi)0) and transfer compressibilities (Delta(tr)kappa(0)(phi)) of diphenhydramine hydrochloride from water to aqueous solutions of sodium chloride and myo-inositol at different temperatures. The transfer volume and transfer compressibility at infinite dilution calculated from (V-phi(0)) and (kappa(0)(phi)) were found to have positive values. The results obtained have been interpreted in terms of various interactions taking place among solute and solvent molecules. (C) 2015 Elsevier Ltd. All rights reserved.