Poly(3,4-ethylenedioxythiophene) (PEDOT) is a kind of conductive polymer. PEDOT doped with polystyrolsulfon acid (PSS) is often used as an interface material of microelectrode to improve the electrochemical characteristic Due to unsymmetrical oxidation and reduction, the properties of PEDOT:PSS need to be improved furtherly. We use Sodium Dodecyl Sulfate (SDS) instead of PSS to dope PEDOT. Electrolytic deposition method is used to modify PEDOT:SDS on the surface of plane gold micro-electrodes fabricated with MEMS process. Compared with PEDOT:PSS, there are significant improvements in the electrochemical performance and anti-aging ability of the PEDOT:SDS modified microelectrode. The impedance of the electrode modified with PEDOT:SDS is nearly half of the impedance of PEDOT:PSS. As for the anti-aging ability, the electrical stability of SDS doped PEDOT is 3.5 times longer than the electrical stability of PSS. (C) 2015 Elsevier B.V. All rights reserved.