We demonstrated a facile method for supporting platinum nanoparticles (PtNPs) on polyaniline (PANI)/mesoporous silica film (MSF). The MSF with mesochannels perpendicular to the underlying electrode surface can confine the electrodeposition of PANI and improve the mechanical strength of PANI The secondary amines and tertiary imines on the PANI backbone can readily complex with PtCl62- ions, which can be further reduced to generate Pt nanoparticles (NPs). The obtained PtNPs@PANI/MSF hybrid material was characterized by transmission electron microscopy and energy dispersive X-ray spectroscopic analysis. It also exhibited a good electrocatalytic activity toward oxidation of H2O2 and can be used to detect H2O2 with a high sensitivity (50 mu A mM(-1)) in a wide concentration range (1.0-2000 mu M). (C) 2014 Elsevier B.V. All rights reserved.