The present study describes a new approach for the investigation of electrocatalytic oxidation of butylated hydroxyanisole (BHA) by using a glassy carbon electrode modified by iridium oxide nanoparticles (GCE/IrOxNPs). IrOxNPs are grown on a GCE by electrodepositing method. It was observed that GCE/IrOxNPs showed a significant electrocatalytic activity toward BHA oxidation. Various experimental parameters influencing the electrochemical behavior of the modified electrode were optimized by varying the scan rates and pH. Cyclic voltammetric studies showed that the catalytic peak current of GCE/IrOxNPs was amplified approximately to 5 times in comparison with the bare GCE. The detection limit, sensitivity, and catalytic rate constant (k(cat)) of the modified electrode toward BHA were 100 nM, 113 nA mu M-1, and 1.1 x 104 M-1 s(-1), respectively, at linear concentration range of up to 280 mu M. The modified electrode showed a good electrochemical response in terms of sensitivity and stability. (C) 2014 Elsevier B.V. All rights reserved.