In this article, for the first time the possibility of the application of an in situ plated lead film electrode to adsorptive stripping voltammetric determinations of organic compounds at alkaline conditions, to pH of 13.3 was showed. As an example of the application of such electrode a procedure for disopyramide determination by adsorptive stripping voltammetry was elaborated. In non-deaerated solutions of ammonium buffer and sodium hydroxide, an in situ plated lead film electrode exhibited well-developed stripping voltammetric signals for disopyramide. For stabilization of Pb(II) at mild alkaline conditions, potassium sodium tartrate was added to an ammonium buffer used as a supporting electrolyte. The proposed voltammetric procedure was applied to disopyramide determination in pharmaceutical formulation. (C) 2012 Elsevier B.V. All rights reserved.