The effects of equal channel angular pressing (ECAP) and subsequent rolling path on the evolutions of rolling texture and flow stress anisotropy in the finally cold-rolled copper sheet was investigated. Copper billets processed by 1, 2, 4, and 8 passes of ECAP were subjected to cold rolling via three different paths: unidirectional rolling along extrusion or transverse direction of ECAP, or cross rolling. The microstructure, texture, and flow stress were characterized by EBSD, TEM, XRD, and tensile testing, respectively. The rolling texture was found transformed from copper-type to brass-type as the initial prerolling microstructure was refined from coarse grained to ultrafine grained (UFG) by multipass ECAP; Cross rolling, which is conventionally considered effective in reducing texture strength and thus mechanical anisotropy in coarse-grained materials, has proven to be ineffective in UFG copper. The flow stress anisotropy in the rolled copper sheet was found mainly controlled by the microstructural-dependent anisotropy of critical resolved shear stress rather than texture strength, and this leads to decrease of flow stress anisotropy in the cold-rolled copper sheet upon the increase in the number of preprocessing ECAP passes.