Ni-Cu catalysts with different SiO2 compositions were prepared via supercritical antisolvent (SAS) precipitation. The calcination and reduction of the SAS Ni-Cu catalysts were investigated by X-ray diffraction, SEM and TEM to determine the influence of various SiO2 contents on the Ni-Cu catalyst morphology. SiO2 addition (>30 wt.%) prevents the sintering of metal particles and increases dispersion, specific surface area and accessibility of Ni-Cu particles. These Ni-Cu catalysts can be used for various processes, such as fast oil pyrolysis, aqueous-phase hydrodeoxygenation, and methane decomposition. The facile approach suggested opens unique opportunities for the synthesis of multicomponent metal supported catalysts with high active phase content (>50 wt.%) of nanosized (<10 nm) metal particles. (C) 2016 Elsevier B.V. All rights reserved.