Concentration and temperature-sensitive assembling behavior of polyethyleneimine-cinnamic acid conjugate and its release-controlling property in monoolein cubic phase

Hong Zhang; Jin-Chul Kim

Journal of Industrial and Engineering Chemistry, Vol.36, 215-223, April, 2016

DOI10.1016/j.jiec.2016.02.003 Export Citation

Concentration and temperature-sensitive assembling behavior of polyethyleneimine-cinnamic acid conjugate and its release-controlling property in monoolein cubic phase

Hong Zhang, and Jin-Chul Kim^†

College of Biomedical Science and Institute of Bioscience and Biotechnology, Kangwon National University, 192-1, Hyoja 2 dong, Chuncheon 200-701, Kangwon-do, Republic of Korea

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Temperature-responsive monoolein (MO) cubic phase was prepared by including polyethyleneimine (PEI) and cinnamic acid (CA) in the cubic phase. PEI/CA aqueous solution exhibited reversible upper critical solution temperature (UCST) behavior. CA and PEI was included in the cubic phase so that the concentrations were the same as those in PEI/CA solution which exhibited reversible UCST behavior from 32 °C to 50 °C. The maximum release degree of methylene blue observed above UCST (12.5% at 45 °C and 13.1% at 50 °C) was apparently higher than the maximum release degree below UCST (4.1% at 25 °C and 4.3% at 30 °C).

Keywords:Polyethyleneimine;Cinnamic acid;Phase transition temperature;Cubic Phase;Release

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[1] Kulkarni CV, Wachter W, Iglesias-Salto G, Engelskirchen S, Ahualli S, Phys. Chem. Chem. Phys., 13, 3004 (2011)

[2] Seo HJ, Kim JC, J. Ind. Eng. Chem., 18(1), 88 (2012)

[3] Zhang H, Kim JC, Colloids Surf. A: Physicochem. Eng. Asp., 465, 59 (2015)

[4] Kwon TK, Kim JC, Drug Dev. Ind. Pharm., 37, 56 (2011)

[5] Kwon TK, Kim JC, J. Dispersion Sci. Technol., 32, 480 (2011)

[6] Negrini R, Mezzenga R, Langmuir, 27(9), 5296 (2011)

[7] Lee MS, Kim JC, Polym. Eng. Sci., 54(1), 227 (2014)

[8] Choi JH, Lee HY, Kim JC, Kim YC, J. Ind. Eng. Chem., 13(3), 380 (2007)

[9] Kwon TK, Kim JC, Biomacromolecules, 12(2), 466 (2011)

[10] Shah JC, Sadhale Y, Chilukuri DM, Adv. Drug Deliv. Rev., 47, 229 (2001)

[11] Kim JC, Lee KU, Shin WC, Lee HY, Kim JD, Kim YC, Tae G, Lee KY, Lee SJ, Kim JD, Colloids Surf. B: Biointerfaces, 36, 161 (2004)

[12] Park TG, Biomaterials, 20, 517 (1999)

[13] Dash S, Murthy PN, Nath L, Chowdhury P, Acta Polym. Pharm., 67, 217 (2010)

[14] Siepmann J, Peppas NA, Adv. Drug Deliv. Rev., 48, 139 (2001)

[15] Urbanus J, Product Removal by In-situ Crystallization, TU Delft, Delft, 2001.