A PdO/MnO (x) /CeO2-ZrO2 catalyst was prepared by a two-step impregnation method. PdO/CeO2-ZrO2, PdO/Al2O3, PdO/MnO (x) /Al2O3, CeO2-ZrO2, and MnO (x) /CeO2-ZrO2 catalysts were also prepared for reference. The textural and surface properties of the catalysts were characterized by X-ray diffraction, Brunauer-Emmett-Teller, Raman spectroscopy, X-ray photoelectron spectroscopy, ultraviolet visible spectroscopy, and CO chemisorption. The redox properties and catalytic activity of the catalysts were evaluated by H-2 temperature-programmed reduction (H-2-TPR) and water-gas shift (WGS) reaction measurements, respectively. The addition of manganese oxide enhances the WGS activity of PdO/CeO2-ZrO2 catalyst significantly. It is ascribed to the improved redox property of the catalyst arising mainly from the Mn-Ce interaction at the interface and the formation of metallic Pd species that resulted from interacting with manganese oxide.