The main objective of this research was to appraise the changes in mineral content and antioxidant attributes of Portulaca oleracea over different growth stages. The antioxidant activity was measured using 1,1-diphenyl-2-picrylhydrazyl (DPPH), ferric-reducing antioxidant power (FRAP) assays. The iodine titration method was used to determine the ascorbic acid content (AAC). DPPH scavenging (IC50) capacity ranged from 1.30 +/- 0.04 to 1.71 +/- 0.04 mg/mL, while the ascorbic acid equivalent antioxidant activity (AEAC) values were 229.5 +/- 7.9 to 319.3 +/- 8.7 mg AA/100 g, total phenol content (TPC) varied from 174.5 +/- 8.5 to 348.5 +/- 7.9 mg GAE/100 g. AAC 60.5 +/- 2.1 to 86.5 +/- 3.9 mg/100 g and FRAP 1.8 +/- 0.1 to 4.3 +/- 0.1 mg GAE/g. There was good correlation between the results of TPC and AEAC, and between IC50 and FRAP assays (r(2) > 0.9). The concentrations of Ca, Mg, K, Fe and Zn increased with plant maturity. Calcium (Ca) was negatively correlated with sodium (Na) and chloride (Cl), but positively correlated with magnesium (Mg), potassium (K), iron (Fe) and zinc (Zn). Portulaca olerecea cultivars could be used as a source of minerals and antioxidants, especially for functional food and nutraceutical applications.